TAS2R50 (taste 2 receptor member 50)

2014-11-01

Identity

HGNC

TAS2R50

LOCATION

12p13.2

LOCUSID

259296

ALIAS

T2R50,T2R51,TAS2R51

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 259296
MIM: 609627
HGNC: 18882
Ensembl: ENSG00000212126

Variants:

dbSNP: 259296
ClinVar: 259296
TCGA: ENSG00000212126
COSMIC: TAS2R50

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000212126	ENST00000506868	P59544

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Class C/3 (Metabotropic glutamate/pheromone receptors)	REACTOME	R-HSA-420499
G alpha (i) signalling events	REACTOME	R-HSA-418594
GPCR downstream signaling	REACTOME	R-HSA-388396
GPCR ligand binding	REACTOME	R-HSA-500792
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
Taste transduction	KEGG	ko04742
Taste transduction	KEGG	hsa04742

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References

Pubmed ID	Year	Title	Citations
19023099	2009	Gene variants associated with ischemic stroke: the cardiovascular health study.	20
19023099	2009	Gene variants associated with ischemic stroke: the cardiovascular health study.	20
19709766	2011	Variations of specific non-candidate genes and risk of myocardial infarction: a replication study.	7
19709766	2011	Variations of specific non-candidate genes and risk of myocardial infarction: a replication study.	7
19817411	2009	The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.	29
22192511	2012	KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.	15
22192511	2012	KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.	15
28366770	2017	A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture.	16
28366770	2017	A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture.	16
32227702	2020	Polymorphism of TAS2R3, TAS2R5, TAS2R19, and TAS2R50 genes and bitter food intake frequency inelderly woman.	1

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Citation

Dessen P

TAS2R50 (taste 2 receptor member 50)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74503