Identity
HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
C12orf38,JBTS24,MKS8,TECT2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79867
MIM: 613846
HGNC: 25774
Ensembl: ENSG00000168778
Variants:
dbSNP: 79867
ClinVar: 79867
TCGA: ENSG00000168778
COSMIC: TCTN2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000168778 | ENST00000303372 | Q96GX1 |
| ENSG00000168778 | ENST00000426174 | Q96GX1 |
| ENSG00000168778 | ENST00000541523 | F5H6G0 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Organelle biogenesis and maintenance | REACTOME | R-HSA-1852241 |
| Cilium Assembly | REACTOME | R-HSA-5617833 |
| Anchoring of the basal body to the plasma membrane | REACTOME | R-HSA-5620912 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36278455 | 2023 | LncRNA TCTN2 Promotes the Malignant Development of Hepatocellular Carcinoma via Regulating mIR-1285-3p/ARF6 Axis. | 0 |
| 36278455 | 2023 | LncRNA TCTN2 Promotes the Malignant Development of Hepatocellular Carcinoma via Regulating mIR-1285-3p/ARF6 Axis. | 0 |
| 33590725 | 2021 | A founder mutation in TCTN2 causes Meckel-Gruber syndrome type 8 among Jews of Ethiopian and Yemenite origin. | 1 |
| 33590725 | 2021 | A founder mutation in TCTN2 causes Meckel-Gruber syndrome type 8 among Jews of Ethiopian and Yemenite origin. | 1 |
| 32655147 | 2020 | Two novel TCTN2 mutations cause Meckel-Gruber syndrome. | 3 |
| 32655147 | 2020 | Two novel TCTN2 mutations cause Meckel-Gruber syndrome. | 3 |
| 31050183 | 2019 | Overexpression of lncRNA TCTN2 protects neurons from apoptosis by enhancing cell autophagy in spinal cord injury. | 20 |
| 31050183 | 2019 | Overexpression of lncRNA TCTN2 protects neurons from apoptosis by enhancing cell autophagy in spinal cord injury. | 20 |
| 29866362 | 2018 | Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening. | 8 |
| 29866362 | 2018 | Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening. | 8 |
| 21462283 | 2011 | A TCTN2 mutation defines a novel Meckel Gruber syndrome locus. | 40 |
| 21565611 | 2011 | Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. | 352 |
| 21462283 | 2011 | A TCTN2 mutation defines a novel Meckel Gruber syndrome locus. | 40 |
| 21565611 | 2011 | Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. | 352 |
Citation
Dessen P
TCTN2 (tectonic family member 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/74596/tctn2-(tectonic-family-member-2)
