TEAD3 (TEA domain transcription factor 3)

2014-11-01  

Identity

HGNC
LOCATION
6p21.31
LOCUSID
ALIAS
DTEF-1,ETFR-1,TEAD-3,TEAD5,TEF-5,TEF5
FUSION GENES

Other Information

Locus ID:

NCBI: 7005
MIM: 603170
HGNC: 11716
Ensembl: ENSG00000007866

Variants:

dbSNP: 7005
ClinVar: 7005
TCGA: ENSG00000007866
COSMIC: TEAD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007866ENST00000338863A0A1X7SBS4
ENSG00000007866ENST00000402886B5MCM0
ENSG00000007866ENST00000639578Q99594

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Hippo signalingKEGGhsa_M00683
Hippo signalingKEGGM00683
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369071392023TEAD3 inhibits the proliferation and metastasis of prostate cancer via suppressing ADRBK2.1
369071392023TEAD3 inhibits the proliferation and metastasis of prostate cancer via suppressing ADRBK2.1
315414522020YAP/TEAD3 signal mediates cardiac lineage commitment of human-induced pluripotent stem cells.13
321427942020TEAD1 and TEAD3 Play Redundant Roles in the Regulation of Human Epidermal Proliferation.10
315414522020YAP/TEAD3 signal mediates cardiac lineage commitment of human-induced pluripotent stem cells.13
321427942020TEAD1 and TEAD3 Play Redundant Roles in the Regulation of Human Epidermal Proliferation.10
311386782019VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle.30
311386782019VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle.30
259954502015Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.18
2648775520159p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells.30
259954502015Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.18
2648775520159p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells.30
235765522013YAP/TEAD-mediated transcription controls cellular senescence.84
235765522013YAP/TEAD-mediated transcription controls cellular senescence.84
151312592004Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1.17

Citation

Dessen P

TEAD3 (TEA domain transcription factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74608/tead3-(tea-domain-transcription-factor-3)