TGOLN2 (trans-golgi network protein 2)

2014-11-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
TGN38,TGN46,TGN48,TGN51,TTGN2,hTGN46,hTGN48,hTGN51
FUSION GENES

Other Information

Locus ID:

NCBI: 10618
MIM: 603062
HGNC: 15450
Ensembl: ENSG00000152291

Variants:

dbSNP: 10618
ClinVar: 10618
TCGA: ENSG00000152291
COSMIC: TGOLN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152291ENST00000377386O43493
ENSG00000152291ENST00000398263O43493
ENSG00000152291ENST00000409015O43493
ENSG00000152291ENST00000444342O43493

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384666282024Sorting of secretory proteins at the trans-Golgi network by human TGN46.3
386703942024Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer.0
384666282024Sorting of secretory proteins at the trans-Golgi network by human TGN46.3
386703942024Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer.0
342447812021Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.5
342447812021Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.5
242212502014The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.45
242212502014The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.45
200862472010Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion.22
201383912010Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin.20
204680572010Case-control association study of TGOLN2 in attempted suicide.2
204680572010Case-control association study of TGOLN2 in attempted suicide.2
200862472010Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion.22
201383912010Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin.20
204680572010Case-control association study of TGOLN2 in attempted suicide.2

Citation

Dessen P

TGOLN2 (trans-golgi network protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74663/haematological-explorer/css/lib/humanGenome