THNSL2 (threonine synthase like 2)

2014-11-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
SOFAT,THS2,TSH2
FUSION GENES

Other Information

Locus ID:

NCBI: 55258
MIM: 611261
HGNC: 25602
Ensembl: ENSG00000144115

Variants:

dbSNP: 55258
ClinVar: 55258
TCGA: ENSG00000144115
COSMIC: THNSL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144115ENST00000324166Q86YJ6
ENSG00000144115ENST00000343544Q86YJ6
ENSG00000144115ENST00000377254A8K0C1
ENSG00000144115ENST00000419759C9J3J1
ENSG00000144115ENST00000449349C9JU10

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
328495012020Secreted Osteoclastogenic Factor of Activated T Cells (SOFAT) Is Associated With Rheumatoid Arthritis and Joint Pain: Initial Evidences of a New Pathway.2
328495012020Secreted Osteoclastogenic Factor of Activated T Cells (SOFAT) Is Associated With Rheumatoid Arthritis and Joint Pain: Initial Evidences of a New Pathway.2
294895072019SOFAT as a Putative Marker of Osteoclasts in Bone Lesions.3
294895072019SOFAT as a Putative Marker of Osteoclasts in Bone Lesions.3
264809202016Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat.48
270358492016Expression of SOFAT by T- and B-lineage cells may contribute to bone loss.9
264809202016Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat.48
270358492016Expression of SOFAT by T- and B-lineage cells may contribute to bone loss.9
259166772015In vitro evaluation of the biological effect of SOFAT on osteoblasts.6
259166772015In vitro evaluation of the biological effect of SOFAT on osteoblasts.6
236194712013Secreted osteoclastogenic factor of activated T cells (SOFAT), a novel osteoclast activator, in chronic periodontitis.17
236194712013Secreted osteoclastogenic factor of activated T cells (SOFAT), a novel osteoclast activator, in chronic periodontitis.17
212998922011Bimodal distribution of RNA expression levels in human skeletal muscle tissue.22
212998922011Bimodal distribution of RNA expression levels in human skeletal muscle tissue.22
198770522009A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner.36

Citation

Dessen P

THNSL2 (threonine synthase like 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74678/thnsl2-(threonine-synthase-like-2)