Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 353376
MIM: 608321
HGNC: 21354
Ensembl: ENSG00000243414
Variants:
dbSNP: 353376
ClinVar: 353376
TCGA: ENSG00000243414
COSMIC: TICAM2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000243414 | ENST00000427199 | Q86XR7 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 29440514 | 2018 | SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. | 23 |
| 29440514 | 2018 | SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. | 23 |
| 28630139 | 2017 | Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling. | 18 |
| 28630139 | 2017 | Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling. | 18 |
| 25521228 | 2015 | Polymorphisms in TICAM2 and IL1B are associated with TB. | 34 |
| 26408662 | 2015 | Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2. | 1 |
| 25521228 | 2015 | Polymorphisms in TICAM2 and IL1B are associated with TB. | 34 |
| 26408662 | 2015 | Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2. | 1 |
| 24812060 | 2014 | The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4. | 20 |
| 25211222 | 2014 | The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production. | 9 |
| 25385819 | 2014 | TRAM is required for TLR2 endosomal signaling to type I IFN induction. | 65 |
| 24812060 | 2014 | The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4. | 20 |
| 25211222 | 2014 | The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production. | 9 |
| 25385819 | 2014 | TRAM is required for TLR2 endosomal signaling to type I IFN induction. | 65 |
| 23136947 | 2013 | MyD88 or TRAM knockdown regulates interleukin (IL)-6, IL-8, and CXCL12 mRNA expression in human gingival and periodontal ligament fibroblasts. | 12 |
Citation
Dessen P
TICAM2 (toll like receptor adaptor molecule 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/74694/ticam2-(toll-like-receptor-adaptor-molecule-2)
