TMEM129 (transmembrane protein 129, E3 ubiquitin ligase)

2014-11-01  

Identity

HGNC
TMEM129
LOCATION
4p16.3
LOCUSID
92305
ALIAS
D4S2561E

Other Information

Locus ID:

NCBI: 92305
MIM: 615975
HGNC: 25137
Ensembl: ENSG00000168936

Variants:

dbSNP: 92305
ClinVar: 92305
TCGA: ENSG00000168936
COSMIC: TMEM129

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168936ENST00000303277A0AVI4
ENSG00000168936ENST00000382936A0AVI4
ENSG00000168936ENST00000460722H7C4I8
ENSG00000168936ENST00000480360H7C4G7
ENSG00000168936ENST00000536901A0AVI4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
359416602022Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk.4
359416602022Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk.4
278542842016The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein.3
278542842016The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein.3
262101832015Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.27
262101832015Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.27
248074182014A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.73
250304482014TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.60
248074182014A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.73
250304482014TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.60
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

TMEM129 (transmembrane protein 129, E3 ubiquitin ligase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74790/tmem129-(transmembrane-protein-129-e3-ubiquitin-ligase)