ARHGAP42 (Rho GTPase activating protein 42)

0000-00-00  

Identity

HGNC
ARHGAP42
LOCATION
11q22.1
LOCUSID
143872
ALIAS
AD031,GRAF3,TMEM133

Other Information

Locus ID:

NCBI: 143872
MIM: 615936
HGNC: 26545
Ensembl: ENSG00000165895

Variants:

dbSNP: 143872
ClinVar: 143872
TCGA: ENSG00000165895
COSMIC: ARHGAP42

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165895ENST00000298815A6NI28
ENSG00000165895ENST00000303130A0A499FIA2
ENSG00000165895ENST00000524892E9PJK4
ENSG00000165895ENST00000529535H0YEJ7
ENSG00000165895ENST00000531183H0YDU1

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
243359962013The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension.19
281126832017Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.8
309031112019Haploinsufficiency of ARHGAP42 is associated with hypertension.3
318867192020Transcriptional and posttranscriptional regulation of the SMC-selective blood pressure-associated gene, ARHGAP42.1

Citation

Dessen P

ARHGAP42 (Rho GTPase activating protein 42)

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/gene/74797/arhgap42-(rho-gtpase-activating-protein-42)