Identity
HGNC
LOCATION
12q21.32
LOCUSID
ALIAS
LIS8,SMILE
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 160418
MIM: 617218
HGNC: 26899
Ensembl: ENSG00000139324
Variants:
dbSNP: 160418
ClinVar: 160418
TCGA: ENSG00000139324
COSMIC: TMTC3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000139324 | ENST00000266712 | Q6ZXV5 |
| ENSG00000139324 | ENST00000547034 | F8VRY4 |
| ENSG00000139324 | ENST00000549011 | F8W044 |
| ENSG00000139324 | ENST00000551088 | F8VR71 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35982901 | 2022 | A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell Carcinoma Progression by Activating GRP78/PERK Signaling Pathway. | 7 |
| 35982901 | 2022 | A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell Carcinoma Progression by Activating GRP78/PERK Signaling Pathway. | 7 |
| 33436046 | 2021 | Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites. | 9 |
| 34794738 | 2021 | The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue. | 3 |
| 33436046 | 2021 | Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites. | 9 |
| 34794738 | 2021 | The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue. | 3 |
| 28973932 | 2017 | Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. | 48 |
| 28973932 | 2017 | Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. | 48 |
| 21956870 | 2012 | mSmile is necessary for bronchial smooth muscle and alveolar myofibroblast development. | 9 |
| 21956870 | 2012 | mSmile is necessary for bronchial smooth muscle and alveolar myofibroblast development. | 9 |
| 21603654 | 2011 | The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response. | 23 |
| 21603654 | 2011 | The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response. | 23 |
Citation
Dessen P
TMTC3 (transmembrane O-mannosyltransferase targeting cadherins 3)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/75023/tmtc3-(transmembrane-o-mannosyltransferase-targeting-cadherins-3)
