Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 121278
MIM: 607478
HGNC: 20692
Ensembl: ENSG00000139287
Variants:
dbSNP: 121278
ClinVar: 121278
TCGA: ENSG00000139287
COSMIC: TPH2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000139287 | ENST00000333850 | Q8IWU9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713257 | Selective serotonin reuptake inhibitors | Chemical | Literature, MultilinkAnnotation | associated | 24930681 | ||
| PA447207 | Depressive Disorder | Disease | ClinicalAnnotation | associated | PD | 23510446 | |
| PA447278 | Depression | Disease | ClinicalAnnotation | associated | PD | 18496129 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 18496129 | |
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 23510446 | |
| PA450522 | mirtazapine | Chemical | ClinicalAnnotation | associated | PD | 18496129 | |
| PA451866 | venlafaxine | Chemical | ClinicalAnnotation | associated | PD | 18496129 | |
| PA452229 | antidepressants | Chemical | ClinicalAnnotation | associated | PD | 18496129 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36980311 | 2023 | HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-α2a and Oral Ribavirin (PEG-IFN-α2a/RBV). | 0 |
| 37104367 | 2023 | Serotonergic modulation of normal and abnormal brain dynamics: The genetic influence of the TPH2 G-703T genotype and DNA methylation on wavelet variance in children and adolescents with and without ADHD. | 1 |
| 37161455 | 2023 | Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population. | 0 |
| 37423455 | 2023 | TPH2-703 G/T polymorphism is associated with stress, depression, and psychosocial symptoms in mentally healthy Mexicans. | 0 |
| 38093326 | 2023 | Interaction between childhood trauma experience and TPH2 rs7305115 gene polymorphism in brain gray matter volume. | 0 |
| 36980311 | 2023 | HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-α2a and Oral Ribavirin (PEG-IFN-α2a/RBV). | 0 |
| 37104367 | 2023 | Serotonergic modulation of normal and abnormal brain dynamics: The genetic influence of the TPH2 G-703T genotype and DNA methylation on wavelet variance in children and adolescents with and without ADHD. | 1 |
| 37161455 | 2023 | Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population. | 0 |
| 37423455 | 2023 | TPH2-703 G/T polymorphism is associated with stress, depression, and psychosocial symptoms in mentally healthy Mexicans. | 0 |
| 38093326 | 2023 | Interaction between childhood trauma experience and TPH2 rs7305115 gene polymorphism in brain gray matter volume. | 0 |
| 34979191 | 2022 | Meta-analysis of association between TPH2 single nucleotide poiymorphism and depression. | 4 |
| 35337298 | 2022 | Influence and interaction of resting state functional magnetic resonance and tryptophan hydroxylase-2 methylation on short-term antidepressant drug response. | 0 |
| 34979191 | 2022 | Meta-analysis of association between TPH2 single nucleotide poiymorphism and depression. | 4 |
| 35337298 | 2022 | Influence and interaction of resting state functional magnetic resonance and tryptophan hydroxylase-2 methylation on short-term antidepressant drug response. | 0 |
| 32981537 | 2021 | Serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior - a TPH2 imaging genetics approach. | 9 |
Citation
Dessen P
TPH2 (tryptophan hydroxylase 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/75074/tph2-(tryptophan-hydroxylase-2)
