TRDN (triadin)

2014-11-01  

Identity

HGNC
TRDN
LOCATION
6q22.31
LOCUSID
10345
ALIAS
CPVT5,TDN,TRISK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10345
MIM: 603283
HGNC: 12261
Ensembl: ENSG00000186439

Variants:

dbSNP: 10345
ClinVar: 10345
TCGA: ENSG00000186439
COSMIC: TRDN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186439ENST00000334268Q13061
ENSG00000186439ENST00000361029H7BY47
ENSG00000186439ENST00000422596H0Y6P0
ENSG00000186439ENST00000542443Q13061
ENSG00000186439ENST00000546248H9ME53
ENSG00000186439ENST00000628709Q13061
ENSG00000186439ENST00000662930A0A590UJV0

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371639782023Cellular and electrophysiological characterization of triadin knockout syndrome using induced pluripotent stem cell-derived cardiomyocytes.2
371639782023Cellular and electrophysiological characterization of triadin knockout syndrome using induced pluripotent stem cell-derived cardiomyocytes.2
358621022022Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart.9
358621022022Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart.9
344151042021Novel cases of pediatric sudden cardiac death secondary to TRDN mutations presenting as long QT syndrome at rest and catecholaminergic polymorphic ventricular tachycardia during exercise: The TRDN arrhythmia syndrome.5
347364172021Association of decreased triadin expression level with apoptosis of dopaminergic cells in Parkinson's disease mouse model.0
344151042021Novel cases of pediatric sudden cardiac death secondary to TRDN mutations presenting as long QT syndrome at rest and catecholaminergic polymorphic ventricular tachycardia during exercise: The TRDN arrhythmia syndrome.5
347364172021Association of decreased triadin expression level with apoptosis of dopaminergic cells in Parkinson's disease mouse model.0
314375352020A novel homozygous mutation in the TRDN gene causes a severe form of pediatric malignant ventricular arrhythmia.6
314375352020A novel homozygous mutation in the TRDN gene causes a severe form of pediatric malignant ventricular arrhythmia.6
291268802018A heart-enriched antisense long non-coding RNA regulates the balance between cardiac and skeletal muscle triadin.8
291268802018A heart-enriched antisense long non-coding RNA regulates the balance between cardiac and skeletal muscle triadin.8
267689642016Compound Heterozygous Triadin Mutation Causing Cardiac Arrest in Two Siblings.9
275620702016Triadin and CLIMP-63 form a link between triads and microtubules in muscle cells.20
267689642016Compound Heterozygous Triadin Mutation Causing Cardiac Arrest in Two Siblings.9

Citation

Dessen P

TRDN (triadin)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75128/trdn-(triadin)