TRIM39 (tripartite motif containing 39)

2014-11-01  

Identity

HGNC
LOCATION
6p22.1
LOCUSID
ALIAS
RNF23,TFP,TRIM39B
FUSION GENES

Other Information

Locus ID:

NCBI: 56658
MIM: 605700
HGNC: 10065
Ensembl: ENSG00000204599

Variants:

dbSNP: 56658
ClinVar: 56658
TCGA: ENSG00000204599
COSMIC: TRIM39

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204599ENST00000376656Q9HCM9
ENSG00000204599ENST00000376656A0A024RCP5
ENSG00000204599ENST00000376659Q9HCM9
ENSG00000204599ENST00000376659A0A024RCR1
ENSG00000204599ENST00000396547Q9HCM9
ENSG00000204599ENST00000396547A0A024RCP5
ENSG00000204599ENST00000396548Q9HCM9
ENSG00000204599ENST00000396548A0A024RCR1
ENSG00000204599ENST00000396551Q9HCM9
ENSG00000204599ENST00000396551A0A024RCR1
ENSG00000204599ENST00000420746H0Y735
ENSG00000204599ENST00000428404A2AAZ3
ENSG00000204599ENST00000428555A2AAZ2
ENSG00000204599ENST00000428728A2AAZ6
ENSG00000204599ENST00000440271A2AAZ4
ENSG00000204599ENST00000458516A2AAZ5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
351749362022TRIM39 is a poor prognostic factor for patients with estrogen receptor-positive breast cancer and promotes cell cycle progression.2
351749362022TRIM39 is a poor prognostic factor for patients with estrogen receptor-positive breast cancer and promotes cell cycle progression.2
338463032021TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7.12
338463032021TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7.12
333116392020Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci.11
333116392020Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci.11
263635542016TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin.25
263635542016TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin.25
237078102013TRIM39R, but not TRIM39B, regulates type I interferon response.8
237078102013TRIM39R, but not TRIM39B, regulates type I interferon response.8
232132512012TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.23
232132602012Ubiquitylation of p53 by the APC/C inhibitor Trim39.28
232132512012TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.23
232132602012Ubiquitylation of p53 by the APC/C inhibitor Trim39.28
208757972010TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B∗51 and -A∗26.21

Citation

Dessen P

TRIM39 (tripartite motif containing 39)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75151/trim39-(tripartite-motif-containing-39)