TRMT112 (tRNA methyltransferase activator subunit 11-2)

2014-11-01  

Identity

HGNC
TRMT112
LOCATION
11q13.1
LOCUSID
51504
ALIAS
HSPC152,HSPC170,TRM112,TRMT11-2,hTrm112
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51504
MIM: 618630
HGNC: 26940
Ensembl: ENSG00000173113

Variants:

dbSNP: 51504
ClinVar: 51504
TCGA: ENSG00000173113
COSMIC: TRMT112

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173113ENST00000308774Q9UI30
ENSG00000173113ENST00000535126F5GZZ7
ENSG00000173113ENST00000535750F5GYQ2
ENSG00000173113ENST00000539854F5GX77
ENSG00000173113ENST00000544844Q9UI30
ENSG00000173113ENST00000544844A0A024R565

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation TerminationREACTOMER-HSA-72764
Gene ExpressionREACTOMER-HSA-74160
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
MethylationREACTOMER-HSA-156581
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315
rRNA processingREACTOMER-HSA-72312
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
350888872022WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15.19
350888872022WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15.19
346699602021THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates.21
349483882021Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor.11
346699602021THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates.21
349483882021Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor.11
329694632020Structural insight into HEMK2-TRMT112-mediated glutamine methylation.6
329694632020Structural insight into HEMK2-TRMT112-mediated glutamine methylation.6
313282272019The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.230
314663822019The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells.9
313282272019The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.230
314663822019The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells.9
258516042015The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.81
262141852015The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome Pathway.18
258516042015The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.81

Citation

Dessen P

TRMT112 (tRNA methyltransferase activator subunit 11-2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75196/trmt112-(trna-methyltransferase-activator-subunit-11-2)