TST (thiosulfate sulfurtransferase)

2014-11-01  

Identity

HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
RDS

Other Information

Locus ID:

NCBI: 7263
MIM: 180370
HGNC: 12388
Ensembl: ENSG00000128311

Variants:

dbSNP: 7263
ClinVar: 7263
TCGA: ENSG00000128311
COSMIC: TST

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128311ENST00000249042Q16762
ENSG00000128311ENST00000249042A0A384NKQ2
ENSG00000128311ENST00000403892Q16762
ENSG00000128311ENST00000403892A0A384NKQ2
ENSG00000128311ENST00000438203B1AH48
ENSG00000128311ENST00000622841Q16762
ENSG00000128311ENST00000622841A0A384NKQ2

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Sulfur metabolismKEGGko00920
Sulfur metabolismKEGGhsa00920
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Sulfur relay systemKEGGko04122
Sulfur relay systemKEGGhsa04122
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Sulfur amino acid metabolismREACTOMER-HSA-1614635
Degradation of cysteine and homocysteineREACTOMER-HSA-1614558
Sulfide oxidation to sulfateREACTOMER-HSA-1614517

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
320617762020Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases.25
320617762020Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases.25
272705872016Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.34
272705872016Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.34
262696022015Polymorphic Variants of Human Rhodanese Exhibit Differences in Thermal Stability and Sulfur Transfer Kinetics.35
262696022015Polymorphic Variants of Human Rhodanese Exhibit Differences in Thermal Stability and Sulfur Transfer Kinetics.35
233997362013Decreased mucosal sulfide detoxification capacity in patients with Crohn's disease.7
233997362013Decreased mucosal sulfide detoxification capacity in patients with Crohn's disease.7
200998482010Identification of Rack1, EF-Tu and Rhodanese as aging-related proteins in human colonic epithelium by proteomic analysis.10
206638812010Mitochondrial enzyme rhodanese is essential for 5 S ribosomal RNA import into human mitochondria.47
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
200998482010Identification of Rack1, EF-Tu and Rhodanese as aging-related proteins in human colonic epithelium by proteomic analysis.10
206638812010Mitochondrial enzyme rhodanese is essential for 5 S ribosomal RNA import into human mitochondria.47
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
170352392006Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).81

Citation

Dessen P

TST (thiosulfate sulfurtransferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75263/tst-(thiosulfate-sulfurtransferase)