TTC26 (tetratricopeptide repeat domain 26)

2014-11-01  

Identity

HGNC
TTC26
LOCATION
7q34
LOCUSID
79989
ALIAS
DYF13,IFT56,dyf-13
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79989
MIM: 617453
HGNC: 21882
Ensembl: ENSG00000105948

Variants:

dbSNP: 79989
ClinVar: 79989
TCGA: ENSG00000105948
COSMIC: TTC26

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105948ENST00000343187A0AVF1
ENSG00000105948ENST00000430935A0AVF1
ENSG00000105948ENST00000464848A0AVF1
ENSG00000105948ENST00000474035Q96CU4
ENSG00000105948ENST00000476296F8WEZ4
ENSG00000105948ENST00000478836B7Z6R6
ENSG00000105948ENST00000495038B7Z2T3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
315955282020Biallelic Mutations in Tetratricopeptide Repeat Domain 26 (Intraflagellar Transport 56) Cause Severe Biliary Ciliopathy in Humans.14
326179642020Pituitary stalk interruption syndrome broadens the clinical spectrum of the TTC26 ciliopathy.3
315955282020Biallelic Mutations in Tetratricopeptide Repeat Domain 26 (Intraflagellar Transport 56) Cause Severe Biliary Ciliopathy in Humans.14
326179642020Pituitary stalk interruption syndrome broadens the clinical spectrum of the TTC26 ciliopathy.3
245961492014TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella.47
245961492014TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella.47
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105

Citation

Dessen P

TTC26 (tetratricopeptide repeat domain 26)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75279/chromosome-explorer/gene-explorer/