TUBGCP6 (tubulin gamma complex associated protein 6)

2014-11-01  

Identity

HGNC
LOCATION
22q13.33
LOCUSID
ALIAS
GCP-6,GCP6,MCCRP,MCCRP1,MCPHCR

Other Information

Locus ID:

NCBI: 85378
MIM: 610053
HGNC: 18127
Ensembl: ENSG00000128159

Variants:

dbSNP: 85378
ClinVar: 85378
TCGA: ENSG00000128159
COSMIC: TUBGCP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128159ENST00000248846Q96RT7
ENSG00000128159ENST00000425018H7C2H5
ENSG00000128159ENST00000434349H7C358
ENSG00000128159ENST00000439308E7EQL8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Recruitment of NuMA to mitotic centrosomesREACTOMER-HSA-380320

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370313782023Biallelic variants in TUBGCP6 result in microcephaly and chorioretinopathy 1: Report of four cases and a literature review.0
370313782023Biallelic variants in TUBGCP6 result in microcephaly and chorioretinopathy 1: Report of four cases and a literature review.0
349545202022SF3B14 is involved in the centrosome regulation through splicing of TUBGCP6 pre-mRNA.1
349545202022SF3B14 is involved in the centrosome regulation through splicing of TUBGCP6 pre-mRNA.1
331371952020Genotype Phenotype Correlation and Variability in Microcephaly Associated With Chorioretinopathy or Familial Exudative Vitreoretinopathy.11
331371952020Genotype Phenotype Correlation and Variability in Microcephaly Associated With Chorioretinopathy or Familial Exudative Vitreoretinopathy.11
310776652019Clinical and Molecular Characterization of Familial Exudative Vitreoretinopathy Associated With Microcephaly.11
310776652019Clinical and Molecular Characterization of Familial Exudative Vitreoretinopathy Associated With Microcephaly.11
222795242012Genetic mapping and exome sequencing identify variants associated with five novel diseases.145
223029952012GCP6 is a substrate of Plk4 and required for centriole duplication.44
222795242012Genetic mapping and exome sequencing identify variants associated with five novel diseases.145
223029952012GCP6 is a substrate of Plk4 and required for centriole duplication.44
202055912010Host determinants of HIV-1 control in African Americans.91
202055912010Host determinants of HIV-1 control in African Americans.91
171828592007GCP6 binds to intermediate filaments: a novel function of keratins in the organization of microtubules in epithelial cells.21

Citation

Dessen P

TUBGCP6 (tubulin gamma complex associated protein 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75375/