UBE2K (ubiquitin conjugating enzyme E2 K)

2014-11-01  

Identity

HGNC
UBE2K
LOCATION
4p14
LOCUSID
3093
ALIAS
E2-25K,HIP2,HYPG,LIG,UBC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3093
MIM: 602846
HGNC: 4914
Ensembl: ENSG00000078140

Variants:

dbSNP: 3093
ClinVar: 3093
TCGA: ENSG00000078140
COSMIC: UBE2K

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078140ENST00000261427P61086
ENSG00000078140ENST00000445950P61086
ENSG00000078140ENST00000503368P61086
ENSG00000078140ENST00000510719D6RFX1
ENSG00000078140ENST00000510934D6RDM7

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381723692024Simulation and Computational Study of RING Domain Mutants of BRCA1 and Ube2k in AD/PD Pathophysiology.0
389631342024Silencing UBE2K inhibits the growth of glioma cells by inducing the autophagy-related apoptosis.0
381723692024Simulation and Computational Study of RING Domain Mutants of BRCA1 and Ube2k in AD/PD Pathophysiology.0
389631342024Silencing UBE2K inhibits the growth of glioma cells by inducing the autophagy-related apoptosis.0
364813612023UBE2K promotes the malignant progression of hepatocellular carcinoma by regulating c-Myc.3
370031322023Hypoxia-induced UBE2K promotes the malignant progression of HCC.0
364813612023UBE2K promotes the malignant progression of hepatocellular carcinoma by regulating c-Myc.3
370031322023Hypoxia-induced UBE2K promotes the malignant progression of HCC.0
324514382020The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.12
324514382020The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.12
302642122019Hip2 ubiquitin-conjugating enzyme has a role in UV-induced G1/S arrest and re-entry.6
309017252019Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia.7
302642122019Hip2 ubiquitin-conjugating enzyme has a role in UV-induced G1/S arrest and re-entry.6
309017252019Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia.7
297251242018Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K.7

Citation

Dessen P

UBE2K (ubiquitin conjugating enzyme E2 K)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75418/case-report-explorer/meetings/