UBN1 (ubinuclein 1)

2014-11-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
VT,VT4
FUSION GENES

Other Information

Locus ID:

NCBI: 29855
MIM: 609771
HGNC: 12506
Ensembl: ENSG00000118900

Variants:

dbSNP: 29855
ClinVar: 29855
TCGA: ENSG00000118900
COSMIC: UBN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118900ENST00000262376Q9NPG3
ENSG00000118900ENST00000396658Q9NPG3
ENSG00000118900ENST00000586716K7EJT1
ENSG00000118900ENST00000587027K7ER78
ENSG00000118900ENST00000589191K7ESM4
ENSG00000118900ENST00000590769Q9NPG3
ENSG00000118900ENST00000592120K7EQR1

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379499722023Activation-induced cytidine deaminase an antibody diversification enzyme interacts with chromatin modifier UBN1 in B-cells.0
379499722023Activation-induced cytidine deaminase an antibody diversification enzyme interacts with chromatin modifier UBN1 in B-cells.0
310401822019The HIRA histone chaperone complex subunit UBN1 harbors H3/H4- and DNA-binding activity.5
310401822019The HIRA histone chaperone complex subunit UBN1 harbors H3/H4- and DNA-binding activity.5
300827902018Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit.25
300827902018Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit.25
261598572015Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex.67
261598572015Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex.67
222455832012Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1).12
224013102012Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.19
222455832012Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1).12
224013102012Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.19
210844792011The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells.4
218078932011Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.51
210844792011The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells.4

Citation

Dessen P

UBN1 (ubinuclein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75434/ubn1-(ubinuclein-1)