Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54579
MIM: 606430
HGNC: 12537
Ensembl: ENSG00000240224
Variants:
dbSNP: 54579
ClinVar: 54579
TCGA: ENSG00000240224
COSMIC: UGT1A5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000240224 | ENST00000373414 | P35504 |
| ENSG00000240224 | ENST00000373414 | Q5DSZ9 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165958521 | febuxostat | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA420 | UGT1A1 | Gene | VipGene | associated | 15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514 | ||
| PA444065 | Epilepsy | Disease | ClinicalAnnotation | associated | PK | 28763744 | |
| PA444318 | Gout | Disease | ClinicalAnnotation | associated | PD | 27798726 | |
| PA445601 | Osteosarcoma | Disease | ClinicalAnnotation | associated | PK | 29791011 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA448320 | allopurinol | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PK | 29791011 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451846 | valproic acid | Chemical | ClinicalAnnotation | associated | PK | 28763744 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 29710432 | 2018 | A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding. | 4 |
| 29710432 | 2018 | A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding. | 4 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 19898482 | 2009 | Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. | 105 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 19898482 | 2009 | Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. | 105 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 18223459 | 2008 | Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population. | 10 |
| 18223459 | 2008 | Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population. | 10 |
Citation
Dessen P
UGT1A5 (UDP glucuronosyltransferase family 1 member A5)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/75469/ugt1a5-(udp-glucuronosyltransferase-family-1-member-a5)
