USP35 (ubiquitin specific peptidase 35)

2014-11-01  

Identity

HGNC
USP35
LOCATION
11q14.1
LOCUSID
57558
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57558
HGNC: 20061
Ensembl: ENSG00000118369

Variants:

dbSNP: 57558
ClinVar: 57558
TCGA: ENSG00000118369
COSMIC: USP35

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118369ENST00000526425Q9P2H5
ENSG00000118369ENST00000528910E9PRM2
ENSG00000118369ENST00000529308Q9P2H5
ENSG00000118369ENST00000530267E9PK78
ENSG00000118369ENST00000530546H0YEP1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382501502024Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1.1
382501502024Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1.1
371733912023The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma.0
375941292023USP35 promotes hepatocellular carcinoma progression by protecting PKM2 from ubiquitination‑mediated degradation.2
371733912023The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma.0
375941292023USP35 promotes hepatocellular carcinoma progression by protecting PKM2 from ubiquitination‑mediated degradation.2
346189992022USP35 mitigates endoplasmic reticulum stress-induced apoptosis by stabilizing RRBP1 in non-small cell lung cancer.15
346189992022USP35 mitigates endoplasmic reticulum stress-induced apoptosis by stabilizing RRBP1 in non-small cell lung cancer.15
326783072021Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer.35
339319672021Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin.58
341311142021USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor α.10
344383462021Regulation of survivin protein stability by USP35 is evolutionarily conserved.4
326783072021Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer.35
339319672021Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin.58
341311142021USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor α.10

Citation

Dessen P

USP35 (ubiquitin specific peptidase 35)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75558/meetings/favicon/hgnc