VARS1 (valyl-tRNA synthetase 1)

2014-11-01 Affiliation

Identity

HGNC

VARS1

LOCATION

6p21.33

LOCUSID

7407

ALIAS

G7A,NDMSCA,VARS,VARS2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7407
MIM: 192150
HGNC: 12651
Ensembl: ENSG00000204394

Variants:

dbSNP: 7407
ClinVar: 7407
TCGA: ENSG00000204394
COSMIC: VARS1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204394	ENST00000375663	P26640
ENSG00000204394	ENST00000375663	A0A024RCN6
ENSG00000204394	ENST00000428445	H0Y426
ENSG00000204394	ENST00000440048	A2ABF4

Pathways

Pathway	Source	External ID
Aminoacyl-tRNA biosynthesis	KEGG	ko00970
Aminoacyl-tRNA biosynthesis	KEGG	hsa00970
Aminoacyl-tRNA biosynthesis, eukaryotes	KEGG	hsa_M00359
Aminoacyl-tRNA biosynthesis, eukaryotes	KEGG	M00359
Gene Expression	REACTOME	R-HSA-74160
tRNA Aminoacylation	REACTOME	R-HSA-379724
Cytosolic tRNA aminoacylation	REACTOME	R-HSA-379716

References

Pubmed ID	Year	Title	Citations
37587064	2023	High expression of VARS promotes the growth of multiple myeloma cells by causing imbalance in valine metabolism.	1
37587064	2023	High expression of VARS promotes the growth of multiple myeloma cells by causing imbalance in valine metabolism.	1
34382495	2021	Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease.	5
34382495	2021	Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease.	5
30755602	2019	Biallelic mutations in valyl-tRNA synthetase gene VARS are associated with a progressive neurodevelopmental epileptic encephalopathy.	24
30755602	2019	Biallelic mutations in valyl-tRNA synthetase gene VARS are associated with a progressive neurodevelopmental epileptic encephalopathy.	24
29691655	2018	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.	10
29691655	2018	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.	10
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
19851445	2009	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	58
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	105
19851445	2009	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	58
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	105
16229838	2005	Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit.	8

Citation

Dessen P

VARS1 (valyl-tRNA synthetase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75584/haematological-explorer/tumors-explorer/welcome