Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7407
MIM: 192150
HGNC: 12651
Ensembl: ENSG00000204394
Variants:
dbSNP: 7407
ClinVar: 7407
TCGA: ENSG00000204394
COSMIC: VARS1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000204394 | ENST00000375663 | P26640 |
| ENSG00000204394 | ENST00000375663 | A0A024RCN6 |
| ENSG00000204394 | ENST00000428445 | H0Y426 |
| ENSG00000204394 | ENST00000440048 | A2ABF4 |
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37587064 | 2023 | High expression of VARS promotes the growth of multiple myeloma cells by causing imbalance in valine metabolism. | 1 |
| 37587064 | 2023 | High expression of VARS promotes the growth of multiple myeloma cells by causing imbalance in valine metabolism. | 1 |
| 34382495 | 2021 | Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease. | 5 |
| 34382495 | 2021 | Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease. | 5 |
| 30755602 | 2019 | Biallelic mutations in valyl-tRNA synthetase gene VARS are associated with a progressive neurodevelopmental epileptic encephalopathy. | 24 |
| 30755602 | 2019 | Biallelic mutations in valyl-tRNA synthetase gene VARS are associated with a progressive neurodevelopmental epileptic encephalopathy. | 24 |
| 29691655 | 2018 | Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy. | 10 |
| 29691655 | 2018 | Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy. | 10 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 19851445 | 2009 | High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. | 58 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 19851445 | 2009 | High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. | 58 |
| 19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | 105 |
| 16229838 | 2005 | Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit. | 8 |
Citation
Dessen P
VARS1 (valyl-tRNA synthetase 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/75584/vars1-(valyl-trna-synthetase-1)
