Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 154807
MIM: 608838
HGNC: 21492
Ensembl: ENSG00000196715
Variants:
dbSNP: 154807
ClinVar: 154807
TCGA: ENSG00000196715
COSMIC: VKORC1L1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000196715 | ENST00000360768 | Q8N0U8 |
| ENSG00000196715 | ENST00000434382 | Q8N0U8 |
| ENSG00000196715 | ENST00000648179 | Q8N0U8 |
| ENSG00000196715 | ENST00000648187 | A0A3B3ISV4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA451906 | warfarin | Chemical | ClinicalAnnotation | associated | PD | 29054760 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 29054760 | 2018 | Polymorphisms of vitamin K-related genes (EPHX1 and VKORC1L1) and stable warfarin doses. | 0 |
| 29581108 | 2018 | VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites. | 9 |
| 29743176 | 2018 | Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition. | 21 |
| 29054760 | 2018 | Polymorphisms of vitamin K-related genes (EPHX1 and VKORC1L1) and stable warfarin doses. | 0 |
| 29581108 | 2018 | VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites. | 9 |
| 29743176 | 2018 | Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition. | 21 |
| 24532791 | 2014 | Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration. | 18 |
| 24532791 | 2014 | Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration. | 18 |
| 23928358 | 2013 | VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy. | 28 |
| 23928358 | 2013 | VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy. | 28 |
| 21367861 | 2011 | Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function. | 49 |
| 21367861 | 2011 | Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function. | 49 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 17996924 | 2008 | No association between vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) and the variability of warfarin dose requirement in a Japanese patient population. | 3 |
Citation
Dessen P
VKORC1L1 (vitamin K epoxide reductase complex subunit 1 like 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/75609/vkorc1l1-(vitamin-k-epoxide-reductase-complex-subunit-1-like-1)
