VPS26A (VPS26, retromer complex component A)

2014-11-01  

Identity

HGNC
VPS26A
LOCATION
10q22.1
LOCUSID
9559
ALIAS
HB58,Hbeta58,PEP8A,VPS26
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9559
MIM: 605506
HGNC: 12711
Ensembl: ENSG00000122958

Variants:

dbSNP: 9559
ClinVar: 9559
TCGA: ENSG00000122958
COSMIC: VPS26A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122958ENST00000263559O75436
ENSG00000122958ENST00000373382O75436
ENSG00000122958ENST00000395098O75436
ENSG00000122958ENST00000489656S4R2Y3
ENSG00000122958ENST00000489794S4R3Q6

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368348982023The Prognostic Value and the Oncogenic and Immunological Roles of Vacuolar Protein Sorting Associated Protein 26 A in Pancreatic Adenocarcinoma.2
368348982023The Prognostic Value and the Oncogenic and Immunological Roles of Vacuolar Protein Sorting Associated Protein 26 A in Pancreatic Adenocarcinoma.2
304642272019Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis.4
304642272019Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis.4
269656912017Retromer's Role in Endosomal Trafficking and Impaired Function in Neurodegenerative Diseases.13
269656912017Retromer's Role in Endosomal Trafficking and Impaired Function in Neurodegenerative Diseases.13
272812732016Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score.18
278892392016Structural Mechanism for Cargo Recognition by the Retromer Complex.113
272812732016Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score.18
278892392016Structural Mechanism for Cargo Recognition by the Retromer Complex.113
253673622015Molecular insights into Rab7-mediated endosomal recruitment of core retromer: deciphering the role of Vps26 and Vps35.38
254751422015Genetic variability of the retromer cargo recognition complex in parkinsonism.17
253673622015Molecular insights into Rab7-mediated endosomal recruitment of core retromer: deciphering the role of Vps26 and Vps35.38
254751422015Genetic variability of the retromer cargo recognition complex in parkinsonism.17
244177872014Mutations in VPS26A are not a frequent cause of Parkinson's disease.5

Citation

Dessen P

VPS26A (VPS26, retromer complex component A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75630/vps26a-(vps26-retromer-complex-component-a)