Identity
HGNC
LOCATION
1p12
LOCUSID
ALIAS
NEMMLAS,TrpRS,mtTrpRS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10352
MIM: 604733
HGNC: 12730
Ensembl: ENSG00000116874
Variants:
dbSNP: 10352
ClinVar: 10352
TCGA: ENSG00000116874
COSMIC: WARS2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000116874 | ENST00000235521 | Q9UGM6 |
| ENSG00000116874 | ENST00000369426 | Q9UGM6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37107582 | 2023 | The Expanding Phenotypical Spectrum of WARS2-Related Disorder: Four Novel Cases with a Common Recurrent Variant. | 0 |
| 37107582 | 2023 | The Expanding Phenotypical Spectrum of WARS2-Related Disorder: Four Novel Cases with a Common Recurrent Variant. | 0 |
| 33721618 | 2021 | Mini-TrpRS is essential for IFNγ-induced monocyte-derived giant cell formation. | 0 |
| 33721618 | 2021 | Mini-TrpRS is essential for IFNγ-induced monocyte-derived giant cell formation. | 0 |
| 33007465 | 2020 | A lead candidate functional single nucleotide polymorphism within the WARS2 gene associated with waist-hip-ratio does not alter RNA stability. | 0 |
| 33007465 | 2020 | A lead candidate functional single nucleotide polymorphism within the WARS2 gene associated with waist-hip-ratio does not alter RNA stability. | 0 |
| 28910573 | 2018 | An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function. | 6 |
| 29120065 | 2018 | Biallelic mutations in mitochondrial tryptophanyl-tRNA synthetase cause Levodopa-responsive infantile-onset Parkinsonism. | 20 |
| 28910573 | 2018 | An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function. | 6 |
| 29120065 | 2018 | Biallelic mutations in mitochondrial tryptophanyl-tRNA synthetase cause Levodopa-responsive infantile-onset Parkinsonism. | 20 |
| 28007980 | 2017 | Archaic Adaptive Introgression in TBX15/WARS2. | 56 |
| 28236339 | 2017 | Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability. | 31 |
| 28650581 | 2017 | Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy. | 20 |
| 28905505 | 2017 | Biallelic variants in WARS2 encoding mitochondrial tryptophanyl-tRNA synthase in six individuals with mitochondrial encephalopathy. | 13 |
| 28007980 | 2017 | Archaic Adaptive Introgression in TBX15/WARS2. | 56 |
Citation
Dessen P
WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/75675/wars2-(tryptophanyl-trna-synthetase-2-mitochondrial)
