WDR41 (WD repeat domain 41)

2014-11-01  

Identity

HGNC
WDR41
LOCATION
5q13.3
LOCUSID
55255
ALIAS
MSTP048
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55255
MIM: 617502
HGNC: 25601
Ensembl: ENSG00000164253

Variants:

dbSNP: 55255
ClinVar: 55255
TCGA: ENSG00000164253
COSMIC: WDR41

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164253ENST00000296679Q9HAD4
ENSG00000164253ENST00000296679A0A0S2Z5E0
ENSG00000164253ENST00000503035D6RGW4
ENSG00000164253ENST00000504895D6RH33
ENSG00000164253ENST00000505129B4DK73
ENSG00000164253ENST00000506307D6RB94
ENSG00000164253ENST00000506474D6RIX6
ENSG00000164253ENST00000507029Q9HAD4
ENSG00000164253ENST00000507654D6RJA5
ENSG00000164253ENST00000509701B4DHS8
ENSG00000164253ENST00000509892H0YAI6
ENSG00000164253ENST00000509971D6R9E7
ENSG00000164253ENST00000511036D6RBY6
ENSG00000164253ENST00000511630H0Y9Z3
ENSG00000164253ENST00000511791D6R9M1
ENSG00000164253ENST00000513417D6RA22
ENSG00000164253ENST00000514559D6RE66
ENSG00000164253ENST00000515253H0YAA3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
spleen
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
335972952021Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids.11
335972952021Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids.11
323036542020Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a.43
323945882020Aberrant methylation of WD-repeat protein 41 contributes to tumour progression in triple-negative breast cancer.4
328482482020Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD.39
323036542020Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a.43
323945882020Aberrant methylation of WD-repeat protein 41 contributes to tumour progression in triple-negative breast cancer.4
328482482020Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD.39
299956112018WDR41 supports lysosomal response to changes in amino acid availability.19
299956112018WDR41 supports lysosomal response to changes in amino acid availability.19
271931902016The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.171
271931902016The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.171
215029492011Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search.32
215029492011Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search.32
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

WDR41 (WD repeat domain 41)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75713/wdr41-(wd-repeat-domain-41)