Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 65267
MIM: 300358
HGNC: 14543
Ensembl: ENSG00000196632
Variants:
dbSNP: 65267
ClinVar: 65267
TCGA: ENSG00000196632
COSMIC: WNK3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000196632 | ENST00000354646 | Q9BYP7 |
| ENSG00000196632 | ENST00000375159 | Q9BYP7 |
| ENSG00000196632 | ENST00000458404 | B1AQN8 |
| ENSG00000196632 | ENST00000620763 | A0A087WYK2 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transmembrane transport of small molecules | REACTOME | R-HSA-382551 |
| Ion channel transport | REACTOME | R-HSA-983712 |
| Stimuli-sensing channels | REACTOME | R-HSA-2672351 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA321 | SLC12A3 | Gene | Pathway | associated | 23788015 | ||
| PA33782 | WNK1 | Gene | Pathway | associated | 23788015 | ||
| PA38243 | STK39 | Gene | Pathway | associated | 23788015 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36357569 | 2022 | WNK3 inhibition elicits antitumor immunity by suppressing PD-L1 expression on tumor cells and activating T-cell function. | 1 |
| 36357569 | 2022 | WNK3 inhibition elicits antitumor immunity by suppressing PD-L1 expression on tumor cells and activating T-cell function. | 1 |
| 33439774 | 2021 | WNKs are potassium-sensitive kinases. | 12 |
| 33760209 | 2021 | Advances in the study of the role and molecular mechanism of with‑no‑lysine kinase 3 in nervous system diseases (Review). | 0 |
| 33439774 | 2021 | WNKs are potassium-sensitive kinases. | 12 |
| 33760209 | 2021 | Advances in the study of the role and molecular mechanism of with‑no‑lysine kinase 3 in nervous system diseases (Review). | 0 |
| 32314908 | 2020 | A Phosphorylated Intermediate in the Activation of WNK Kinases. | 10 |
| 32314908 | 2020 | A Phosphorylated Intermediate in the Activation of WNK Kinases. | 10 |
| 30253317 | 2018 | Increased expression of WNK3 in dispersed granule cells in hippocampal sclerosis of mesial temporal lobe epilepsy patients. | 5 |
| 30253317 | 2018 | Increased expression of WNK3 in dispersed granule cells in hippocampal sclerosis of mesial temporal lobe epilepsy patients. | 5 |
| 27378340 | 2016 | WNK3 interacts with NCC. | 0 |
| 27467688 | 2016 | WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway. | 2 |
| 27378340 | 2016 | WNK3 interacts with NCC. | 0 |
| 27467688 | 2016 | WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway. | 2 |
| 26069258 | 2015 | Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke. | 53 |
Citation
Dessen P
WNK3 (WNK lysine deficient protein kinase 3)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/75766/wnk3-(wnk-lysine-deficient-protein-kinase-3)
