ZCWPW1 (zinc finger CW-type and PWWP domain containing 1)

2014-11-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
ZCW1

Other Information

Locus ID:

NCBI: 55063
MIM: 618900
HGNC: 23486
Ensembl: ENSG00000078487

Variants:

dbSNP: 55063
ClinVar: 55063
TCGA: ENSG00000078487
COSMIC: ZCWPW1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078487ENST00000360951Q9H0M4
ENSG00000078487ENST00000398027Q9H0M4
ENSG00000078487ENST00000471336H7C4V9
ENSG00000078487ENST00000472716C9JUV7
ENSG00000078487ENST00000490721Q9H0M4
ENSG00000078487ENST00000490721A0A0S2Z5N7

Expression (GTEx)

0
50
100
150

References

Pubmed IDYearTitleCitations
383102352024A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation.0
383102352024A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation.0
352176072022PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.14
360686162022The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.5
352176072022PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.14
360686162022The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.5
327445062020ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.22
327445062020ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.22
269193932016Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.59
269588122016ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses.10
269193932016Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.59
269588122016ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses.10
247433382014Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings.26
247433382014Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings.26

Citation

Dessen P

ZCWPW1 (zinc finger CW-type and PWWP domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75902/tumors-explorer/