ZFYVE16 (zinc finger FYVE-type containing 16)

2014-11-01 Affiliation

Identity

HGNC

ZFYVE16

LOCATION

5q14.1

LOCUSID

9765

ALIAS

PPP1R69

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9765
MIM: 608880
HGNC: 20756
Ensembl: ENSG00000039319

Variants:

dbSNP: 9765
ClinVar: 9765
TCGA: ENSG00000039319
COSMIC: ZFYVE16

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000039319	ENST00000338008	Q7Z3T8
ENSG00000039319	ENST00000505560	Q7Z3T8
ENSG00000039319	ENST00000507548	H0Y8R0
ENSG00000039319	ENST00000509558	H0YAB1
ENSG00000039319	ENST00000509562	D6RC80
ENSG00000039319	ENST00000510158	Q7Z3T8
ENSG00000039319	ENST00000513789	H0YAA4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
TGF-beta signaling pathway	KEGG	ko04350
TGF-beta signaling pathway	KEGG	hsa04350
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Signal Transduction	REACTOME	R-HSA-162582
Signaling by BMP	REACTOME	R-HSA-201451

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
26944198	2016	Genetic Mutation that May Contribute to Failure of Prolapse Surgery in White Women: A Case-Control Study.	0
26944198	2016	Genetic Mutation that May Contribute to Failure of Prolapse Surgery in White Women: A Case-Control Study.	0
19887107	2010	EGF-induced tyrosine phosphorylation of Endofin is dependent on PI3K activity and proper localization to endosomes.	2
19887107	2010	EGF-induced tyrosine phosphorylation of Endofin is dependent on PI3K activity and proper localization to endosomes.	2
17272273	2007	Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling.	33
17570516	2007	Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.	13
17272273	2007	Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling.	33
17570516	2007	Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.	13
16775010	2006	Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA.	40
16775010	2006	Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA.	40
14613930	2004	Endofin recruits TOM1 to endosomes.	13
14613930	2004	Endofin recruits TOM1 to endosomes.	13

Citation

Dessen P

ZFYVE16 (zinc finger FYVE-type containing 16)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75952/zfyve16-(zinc-finger-fyve-type-containing-16)