Identity
HGNC
LOCATION
10q24.2
LOCUSID
ALIAS
PROTRUDIN,SPG33
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 118813
MIM: 610243
HGNC: 26559
Ensembl: ENSG00000155256
Variants:
dbSNP: 118813
ClinVar: 118813
TCGA: ENSG00000155256
COSMIC: ZFYVE27
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Endocytosis | KEGG | ko04144 |
| Endocytosis | KEGG | hsa04144 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32479595 | 2020 | Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion. | 28 |
| 32917905 | 2020 | Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation. | 36 |
| 33154382 | 2020 | Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS. | 27 |
| 32479595 | 2020 | Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion. | 28 |
| 32917905 | 2020 | Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation. | 36 |
| 33154382 | 2020 | Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS. | 27 |
| 31772151 | 2019 | Protrudin modulates seizure activity through GABA(A) receptor regulation. | 6 |
| 31772151 | 2019 | Protrudin modulates seizure activity through GABA(A) receptor regulation. | 6 |
| 23969831 | 2013 | Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. | 38 |
| 23969831 | 2013 | Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. | 38 |
| 22573551 | 2012 | Role of spastin and protrudin in neurite outgrowth. | 18 |
| 22573551 | 2012 | Role of spastin and protrudin in neurite outgrowth. | 18 |
| 21976701 | 2011 | Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. | 66 |
| 21976701 | 2011 | Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. | 66 |
| 19289470 | 2009 | Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein. | 53 |
Citation
Dessen P
ZFYVE27 (zinc finger FYVE-type containing 27)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/75954/zfyve27-(zinc-finger-fyve-type-containing-27)
