ADGRG3 (adhesion G protein-coupled receptor G3)

2015-06-01  

Identity

HGNC
ADGRG3
LOCATION
16q21
LOCUSID
222487
ALIAS
GPR97,PB99,PGR26
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 222487
MIM: 618441
HGNC: 13728
Ensembl: ENSG00000182885

Variants:

dbSNP: 222487
ClinVar: 222487
TCGA: ENSG00000182885
COSMIC: ADGRG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182885ENST00000333493Q86Y34
ENSG00000182885ENST00000450388F8W8F7
ENSG00000182885ENST00000567991H3BRU4
ENSG00000182885ENST00000568245H3BS78

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
350936392022Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid.1
363027842022GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation.4
350936392022Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid.1
363027842022GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation.4
334084142021Structures of the glucocorticoid-bound adhesion receptor GPR97-G(o) complex.51
334084142021Structures of the glucocorticoid-bound adhesion receptor GPR97-G(o) complex.51
305597452018The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions.16
305597452018The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions.16
241782982013The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42.30
241782982013The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42.30
204244732010L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.0
204244732010L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.0

Citation

Dessen P

ADGRG3 (adhesion G protein-coupled receptor G3)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/76595/meetings/