BCAS4 (breast carcinoma amplified sequence 4)

2004-05-01   Jean-Loup Huret , Sylvie Senon 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
BCAS4
LOCATION
20q13.13
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
55653
ALIAS
CNOL
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

spans 82 kb; orientation direct strand; 19 exons

Transcription

alternate splicings

Proteins

Expression

ubiquitous

Localisation

cytoplasmic

Implicated in

Entity name
BCAS4 is overexpressed in 3.5% of breast cancers, and a hybrid gene BCAS4-BCAS3 was found in breat cancer cell line with a t(17;20)(q23;q13)
Hybrid gene
5 BCAS4 is fused to the 2 last exons (23 and 24) of BCAS3; transcript includes exon 1 from BCAS4 and 21 bp from BCAS3 exon 23; it encodes a 66 aminoacids protein; no reciprocal transcript

Bibliography

Pubmed IDLast YearTitleAuthors
146340232004p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation.Melino G et al

Other Information

Locus ID:

NCBI: 55653
MIM: 607471
HGNC: 14367
Ensembl: ENSG00000124243

Variants:

dbSNP: 55653
ClinVar: 55653
TCGA: ENSG00000124243
COSMIC: BCAS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124243ENST00000358791Q8TDM0
ENSG00000124243ENST00000371608Q8TDM0
ENSG00000124243ENST00000445038A0A0C4DH49
ENSG00000124243ENST00000463943H7C4Y8
ENSG00000124243ENST00000609336A0A0C4DGS6

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
123785252002Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer.41

Citation

Jean-Loup Huret ; Sylvie Senon

BCAS4 (breast carcinoma amplified sequence 4)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/767/bcas4-(breast-carcinoma-amplified-sequence-4)