ADGRA3 (adhesion G protein-coupled receptor A3)

2015-06-01  

Identity

HGNC
ADGRA3
LOCATION
4p15.2
LOCUSID
166647
ALIAS
GPR125,PGR21,TEM5L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 166647
MIM: 612303
HGNC: 13839
Ensembl: ENSG00000152990

Variants:

dbSNP: 166647
ClinVar: 166647
TCGA: ENSG00000152990
COSMIC: ADGRA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152990ENST00000334304Q8IWK6
ENSG00000152990ENST00000502482Q8IWK6
ENSG00000152990ENST00000508133Q8IWK6
ENSG00000152990ENST00000511051D6RER4
ENSG00000152990ENST00000514129D6RDX4

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
174573132007Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia.10
249029692014Evaluation of candidate spermatogonial markers ID4 and GPR125 in testes of adult human cadaveric organ donors.10
302312582018Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/β-Catenin Signaling Pathway.2
316597462019Arrestin-independent constitutive endocytosis of GPR125/ADGRA3.1

Citation

Dessen P

ADGRA3 (adhesion G protein-coupled receptor A3)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/77422/adgra3-(adhesion-g-protein-coupled-receptor-a3)