NUP58 (nucleoporin 58)

2015-09-01 Affiliation

Identity

HGNC

NUP58

LOCATION

13q12.13

LOCUSID

9818

ALIAS

NUP45,NUPL1,PRO2463

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9818
MIM: 607615
HGNC: 20261
Ensembl: ENSG00000139496

Variants:

dbSNP: 9818
ClinVar: 9818
TCGA: ENSG00000139496
COSMIC: NUP58

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000139496	ENST00000381718	Q9BVL2
ENSG00000139496	ENST00000381736	Q9BVL2
ENSG00000139496	ENST00000381747	H7BYF2
ENSG00000139496	ENST00000394327	Q5JRG1
ENSG00000139496	ENST00000463407	Q9BVL2
ENSG00000139496	ENST00000465068	F8WC35
ENSG00000139496	ENST00000481980	F8WCJ8
ENSG00000139496	ENST00000490231	F8WBZ1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
Nuclear pore complex	KEGG	hsa_M00427
Nuclear pore complex	KEGG	M00427
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
SUMOylation	REACTOME	R-HSA-2990846
SUMO E3 ligases SUMOylate target proteins	REACTOME	R-HSA-3108232
SUMOylation of DNA damage response and repair proteins	REACTOME	R-HSA-3108214
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Rev-mediated nuclear export of HIV RNA	REACTOME	R-HSA-165054
Host Interactions of HIV factors	REACTOME	R-HSA-162909
Interactions of Vpr with host cellular proteins	REACTOME	R-HSA-176033
Vpr-mediated nuclear import of PICs	REACTOME	R-HSA-180910
Interactions of Rev with host cellular proteins	REACTOME	R-HSA-177243
Nuclear import of Rev protein	REACTOME	R-HSA-180746
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Transport of Ribonucleoproteins into the Host Nucleus	REACTOME	R-HSA-168271
Influenza Viral RNA Transcription and Replication	REACTOME	R-HSA-168273
Viral Messenger RNA Synthesis	REACTOME	R-HSA-168325
Export of Viral Ribonucleoproteins from Nucleus	REACTOME	R-HSA-168274
NEP/NS2 Interacts with the Cellular Export Machinery	REACTOME	R-HSA-168333
Host Interactions with Influenza Factors	REACTOME	R-HSA-168253
NS1 Mediated Effects on Host Pathways	REACTOME	R-HSA-168276
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
ISG15 antiviral mechanism	REACTOME	R-HSA-1169408
Gene Expression	REACTOME	R-HSA-74160
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
Transport of Mature Transcript to Cytoplasm	REACTOME	R-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing Transcript	REACTOME	R-HSA-159236
Transport of Mature mRNAs Derived from Intronless Transcripts	REACTOME	R-HSA-159234
Transport of the SLBP Dependant Mature mRNA	REACTOME	R-HSA-159230
Transport of the SLBP independent Mature mRNA	REACTOME	R-HSA-159227
Transport of Mature mRNA Derived from an Intronless Transcript	REACTOME	R-HSA-159231
Gene Silencing by RNA	REACTOME	R-HSA-211000
Transcriptional regulation by small RNAs	REACTOME	R-HSA-5578749
Metabolism of non-coding RNA	REACTOME	R-HSA-194441
snRNP Assembly	REACTOME	R-HSA-191859
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Nuclear Envelope Breakdown	REACTOME	R-HSA-2980766
Nuclear Pore Complex (NPC) Disassembly	REACTOME	R-HSA-3301854
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Hexose transport	REACTOME	R-HSA-189200
Glucose transport	REACTOME	R-HSA-70153
Regulation of Glucokinase by Glucokinase Regulatory Protein	REACTOME	R-HSA-170822
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
Regulation of HSF1-mediated heat shock response	REACTOME	R-HSA-3371453
tRNA processing	REACTOME	R-HSA-72306
tRNA processing in the nucleus	REACTOME	R-HSA-6784531
SUMOylation of RNA binding proteins	REACTOME	R-HSA-4570464
SUMOylation of DNA replication proteins	REACTOME	R-HSA-4615885

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34528284	2021	Non-genetic and genetic rewiring underlie adaptation to hypomorphic alleles of an essential gene.	3
34528284	2021	Non-genetic and genetic rewiring underlie adaptation to hypomorphic alleles of an essential gene.	3
26288249	2015	Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.	25
26288249	2015	Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.	25
7531196	1995	Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62.	17
7531196	1995	Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62.	17

Citation

Dessen P

NUP58 (nucleoporin 58)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/77729/nup58-(nucleoporin-58)

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