GPAT4 (glycerol-3-phosphate acyltransferase 4)

2015-09-01  

Identity

HGNC
GPAT4
LOCATION
8p11.21
LOCUSID
137964
ALIAS
1-AGPAT 6,AGPAT6,LPAAT-zeta,LPAATZ,TSARG7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 137964
MIM: 608143
HGNC: 20880
Ensembl: ENSG00000158669

Variants:

dbSNP: 137964
ClinVar: 137964
TCGA: ENSG00000158669
COSMIC: GPAT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158669ENST00000396987Q86UL3
ENSG00000158669ENST00000519853E5RIA1
ENSG00000158669ENST00000520223E5RGW3
ENSG00000158669ENST00000521806E5RHA6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Metabolic pathwaysKEGGhsa01100
Triacylglycerol biosynthesisKEGGhsa_M00089
Triacylglycerol biosynthesisKEGGM00089
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
308463172019CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.50
308463172019CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4.50
241562952013Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes.0
241562952013Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes.0
201819842010GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.52
201819842010GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.52
182387782008AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.78
182387782008AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.78
166258272006Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis.0
166258272006Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis.0

Citation

Dessen P

GPAT4 (glycerol-3-phosphate acyltransferase 4)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/77796/gpat4-(glycerol-3-phosphate-acyltransferase-4)