AGR3 (anterior gradient 3, protein disulphide isomerase family member)

2003-10-01  

Identity

HGNC
AGR3
LOCATION
7p21.1
LOCUSID
155465
ALIAS
AG-3,AG3,BCMP11,HAG3,PDIA18,hAG-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 155465
MIM: 609482
HGNC: 24167
Ensembl: ENSG00000173467

Variants:

dbSNP: 155465
ClinVar: 155465
TCGA: ENSG00000173467
COSMIC: AGR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173467ENST00000310398Q8TD06
ENSG00000173467ENST00000402239B5MC62
ENSG00000173467ENST00000414935H7C040

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
125923732003hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.52
159357012005Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family.41
214513622011The anterior gradient homolog 3 (AGR3) gene is associated with differentiation and survival in ovarian cancer.36
223611112012Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models.15
256666612015The role of AGR2 and AGR3 in cancer: similar but not identical.15
258750932015AGR3 in breast cancer: prognostic impact and suitable serum-based biomarker for early cancer detection.11
247472402014Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma.7
257516682015The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.3
296201962018Combination of TP53 and AGR3 to distinguish ovarian high-grade serous carcinoma from low-grade serous carcinoma.1
258686112015The NS5A protein of hepatitis C virus transcriptionally upregulates the AGR3 gene expression.0

Citation

Dessen P

AGR3 (anterior gradient 3, protein disulphide isomerase family member)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/783/agr3-(anterior-gradient-3-protein-disulphide-isomerase-family-member)