Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54969
MIM: 616614
HGNC: 26051
Ensembl: ENSG00000056050
Variants:
dbSNP: 54969
ClinVar: 54969
TCGA: ENSG00000056050
COSMIC: HPF1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000056050 | ENST00000393381 | Q9NWY4 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37541786 | 2023 | Germline HPF1 retrogene insertion in RB1 gene involved in cancer predisposition. | 0 |
| 37541786 | 2023 | Germline HPF1 retrogene insertion in RB1 gene involved in cancer predisposition. | 0 |
| 33589610 | 2021 | HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones. | 31 |
| 33683197 | 2021 | HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase. | 33 |
| 34210965 | 2021 | Serine-linked PARP1 auto-modification controls PARP inhibitor response. | 40 |
| 34625544 | 2021 | The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome. | 39 |
| 34732825 | 2021 | Dual function of HPF1 in the modulation of PARP1 and PARP2 activities. | 9 |
| 34795260 | 2021 | HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications. | 30 |
| 33589610 | 2021 | HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones. | 31 |
| 33683197 | 2021 | HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase. | 33 |
| 34210965 | 2021 | Serine-linked PARP1 auto-modification controls PARP inhibitor response. | 40 |
| 34625544 | 2021 | The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome. | 39 |
| 34732825 | 2021 | Dual function of HPF1 in the modulation of PARP1 and PARP2 activities. | 9 |
| 34795260 | 2021 | HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications. | 30 |
| 32028527 | 2020 | HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation. | 126 |
Citation
Dessen P
HPF1 (histone PARylation factor 1)
Atlas Genet Cytogenet Oncol Haematol. 2001-01-01
Online version: http://atlasgeneticsoncology.org/gene/78372/hpf1-(histone-parylation-factor-1)
