Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22917
MIM: 195000
HGNC: 13187
Ensembl: ENSG00000149506
Variants:
dbSNP: 22917
ClinVar: 22917
TCGA: ENSG00000149506
COSMIC: ZP1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000149506 | ENST00000278853 | P60852 |
| ENSG00000149506 | ENST00000278853 | V9HWI9 |
| ENSG00000149506 | ENST00000540908 | H0YG11 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Reproduction | REACTOME | R-HSA-1474165 |
| Fertilization | REACTOME | R-HSA-1187000 |
| Interaction With The Zona Pellucida | REACTOME | R-HSA-1300644 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36931917 | 2023 | Novel variants in ZP1, ZP2 and ZP3 associated with empty follicle syndrome and abnormal zona pellucida. | 4 |
| 36931917 | 2023 | Novel variants in ZP1, ZP2 and ZP3 associated with empty follicle syndrome and abnormal zona pellucida. | 4 |
| 35460069 | 2022 | A recurrent ZP1 variant is responsible for oocyte maturation defect with degenerated oocytes in infertile females. | 4 |
| 35773450 | 2022 | A Novel Homozygous Nonsense Mutation in ZP1 Causes Female Infertility due to Empty Follicle Syndrome. | 1 |
| 35460069 | 2022 | A recurrent ZP1 variant is responsible for oocyte maturation defect with degenerated oocytes in infertile females. | 4 |
| 35773450 | 2022 | A Novel Homozygous Nonsense Mutation in ZP1 Causes Female Infertility due to Empty Follicle Syndrome. | 1 |
| 33423275 | 2021 | Novel mutations in ZP1: Expanding the mutational spectrum associated with empty follicle syndrome in infertile women. | 4 |
| 33665726 | 2021 | A novel homozygous nonsense mutation in zona pellucida 1 (ZP1) causes human female empty follicle syndrome. | 6 |
| 33423275 | 2021 | Novel mutations in ZP1: Expanding the mutational spectrum associated with empty follicle syndrome in infertile women. | 4 |
| 33665726 | 2021 | A novel homozygous nonsense mutation in zona pellucida 1 (ZP1) causes human female empty follicle syndrome. | 6 |
| 31909477 | 2020 | Novel ZP1 pathogenic variants identified in an infertile patient and a successful live birth following ICSI treatment. | 5 |
| 32244758 | 2020 | Homozygous Splice Site Mutation in ZP1 Causes Familial Oocyte Maturation Defect. | 10 |
| 32556881 | 2020 | Novel biallelic loss-of-function variants in ZP1 identified in an infertile female with empty follicle syndrome. | 9 |
| 32569527 | 2020 | Zona Pellucida Proteins, Fibrils, and Matrix. | 24 |
| 32573113 | 2020 | Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human. | 23 |
Citation
Dessen P
ZP1 (zona pellucida glycoprotein 1)
Atlas Genet Cytogenet Oncol Haematol. 2001-01-01
Online version: http://atlasgeneticsoncology.org/gene/78457/zp1-(zona-pellucida-glycoprotein-1)
