PYCR3 (pyrroline-5-carboxylate reductase 3)

2017-09-01  

Identity

HGNC
PYCR3
LOCATION
8q24.3
LOCUSID
65263
ALIAS
PYCRL

Other Information

Locus ID:

NCBI: 65263
MIM: 616408
HGNC: 25846
Ensembl: ENSG00000104524

Variants:

dbSNP: 65263
ClinVar: 65263
TCGA: ENSG00000104524
COSMIC: PYCR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104524ENST00000220966A0A0A0MQS1
ENSG00000104524ENST00000377579B5MD87
ENSG00000104524ENST00000433751Q53H96
ENSG00000104524ENST00000447926F8WEI0
ENSG00000104524ENST00000462036A0A087WTU2
ENSG00000104524ENST00000495276Q53H96

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Proline biosynthesis, glutamate => prolineKEGGhsa_M00015
Proline biosynthesis, glutamate => prolineKEGGM00015
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386428272024PYCR3 modulates mtDNA copy number to drive proliferation and doxorubicin resistance in triple-negative breast cancer.2
386428272024PYCR3 modulates mtDNA copy number to drive proliferation and doxorubicin resistance in triple-negative breast cancer.2

Citation

Dessen P

PYCR3 (pyrroline-5-carboxylate reductase 3)

Atlas Genet Cytogenet Oncol Haematol. 2017-09-01

Online version: http://atlasgeneticsoncology.org/gene/78864/new-content/case-report-explorer/