Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 80739
MIM: 606520
HGNC: 13937
Ensembl: ENSG00000204420
Variants:
dbSNP: 80739
ClinVar: 80739
TCGA: ENSG00000204420
COSMIC: MPIG6B
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Hemostasis | REACTOME | R-HSA-109582 |
| Platelet activation, signaling and aggregation | REACTOME | R-HSA-76002 |
| GPVI-mediated activation cascade | REACTOME | R-HSA-114604 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33871931 | 2021 | Detrimental variants in MPIG6B in two children with myelofibrosis: Does immune dysregulation contribute to myelofibrosis? | 4 |
| 33871931 | 2021 | Detrimental variants in MPIG6B in two children with myelofibrosis: Does immune dysregulation contribute to myelofibrosis? | 4 |
| 32386542 | 2020 | Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets. | 74 |
| 32386542 | 2020 | Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets. | 74 |
| 31276734 | 2019 | Case report of a novel MPIG6B gene mutation in a Chinese boy with pancytopenia and splenomegaly. | 5 |
| 31436532 | 2019 | Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. | 18 |
| 31276734 | 2019 | Case report of a novel MPIG6B gene mutation in a Chinese boy with pancytopenia and splenomegaly. | 5 |
| 31436532 | 2019 | Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. | 18 |
| 29898956 | 2018 | Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice. | 18 |
| 29898956 | 2018 | Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice. | 18 |
| 27743390 | 2017 | Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia. | 13 |
| 27743390 | 2017 | Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia. | 13 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 19143814 | 2009 | Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. | 20 |
Citation
Dessen P
MPIG6B (megakaryocyte and platelet inhibitory receptor G6b)
Atlas Genet Cytogenet Oncol Haematol. 2017-09-01
Online version: http://atlasgeneticsoncology.org/gene/78883/mpig6b-(megakaryocyte-and-platelet-inhibitory-receptor-g6b)
