BIK (BCL2 interacting killer)

2003-02-01  

Identity

HGNC
BIK
LOCATION
22q13.2
LOCUSID
638
ALIAS
BIP1,BP4,NBK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 638
MIM: 603392
HGNC: 1051
Ensembl: ENSG00000100290

Variants:

dbSNP: 638
ClinVar: 638
TCGA: ENSG00000100290
COSMIC: BIK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100290ENST00000216115Q13323
ENSG00000100290ENST00000216115A0A024R4X6

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Endocrine resistanceKEGGko01522
Endocrine resistanceKEGGhsa01522

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
349628252022Rhomboid domain containing 1 promotes the growth of non-small cell lung cancer through the activation of EGFR and regulation of the BIK-mediated apoptosis.0
350089222022RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival.4
349628252022Rhomboid domain containing 1 promotes the growth of non-small cell lung cancer through the activation of EGFR and regulation of the BIK-mediated apoptosis.0
350089222022RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival.4
316354992020Correlation of the protein expression of GRP78 and BIK/NBK with prognostic markers in patients with breast cancer and neoadjuvant chemotherapy.4
316354992020Correlation of the protein expression of GRP78 and BIK/NBK with prognostic markers in patients with breast cancer and neoadjuvant chemotherapy.4
313879402019BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.8
314608372019Upregulation of miR-1306-5p decreases cerebral ischemia/reperfusion injury in vitro by targeting BIK.0
313879402019BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.8
314608372019Upregulation of miR-1306-5p decreases cerebral ischemia/reperfusion injury in vitro by targeting BIK.0
284124122017Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis.8
287842602017Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner.11
287968112017Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells.11
284124122017Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis.8
287842602017Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner.11

Citation

Dessen P

BIK (BCL2 interacting killer)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/793/bik-(bcl2-interacting-killer)