BIK (BCL2 interacting killer)

2003-02-01  

Identity

HGNC
LOCATION
22q13.2
LOCUSID
ALIAS
BIP1,BP4,NBK
FUSION GENES

Other Information

Locus ID:

NCBI: 638
MIM: 603392
HGNC: 1051
Ensembl: ENSG00000100290

Variants:

dbSNP: 638
ClinVar: 638
TCGA: ENSG00000100290
COSMIC: BIK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100290ENST00000216115Q13323
ENSG00000100290ENST00000216115A0A024R4X6

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Endocrine resistanceKEGGko01522
Endocrine resistanceKEGGhsa01522

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197677532009Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.225
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
157912102005Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis.113
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
158092952005BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death.60
157675532005The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim.53
216225632011Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK).50
118844142002BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria.47
157310892005Degradation of the proapoptotic proteins Bik, Puma, and Bim with Bcl-2 domain 3 homology in Chlamydia trachomatis-infected cells.46

Citation

Dessen P

BIK (BCL2 interacting killer)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/793/bik-(bcl2-interacting-killer)