Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55243
MIM: 607428
HGNC: 15734
Ensembl: ENSG00000183853
Variants:
dbSNP: 55243
ClinVar: 55243
TCGA: ENSG00000183853
COSMIC: KIRREL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000183853 | ENST00000359209 | Q96J84 |
| ENSG00000183853 | ENST00000360089 | Q5W0F9 |
| ENSG00000183853 | ENST00000368172 | Q5W0G0 |
| ENSG00000183853 | ENST00000368173 | B4DN67 |
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cell-Cell communication | REACTOME | R-HSA-1500931 |
| Nephrin interactions | REACTOME | R-HSA-373753 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37909722 | 2024 | KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway. | 0 |
| 37909722 | 2024 | KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway. | 0 |
| 35177623 | 2022 | Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites. | 7 |
| 36044856 | 2022 | Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers. | 3 |
| 35177623 | 2022 | Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites. | 7 |
| 36044856 | 2022 | Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers. | 3 |
| 32534710 | 2020 | Overexpression of kin of IRRE-Like protein 1 (KIRREL) as a prognostic biomarker for breast cancer. | 3 |
| 32534710 | 2020 | Overexpression of kin of IRRE-Like protein 1 (KIRREL) as a prognostic biomarker for breast cancer. | 3 |
| 31472902 | 2019 | Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome. | 10 |
| 31472902 | 2019 | Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome. | 10 |
| 27044863 | 2016 | Structural Analysis of the Myo1c and Neph1 Complex Provides Insight into the Intracellular Movement of Neph1. | 9 |
| 27044863 | 2016 | Structural Analysis of the Myo1c and Neph1 Complex Provides Insight into the Intracellular Movement of Neph1. | 9 |
| 24554715 | 2014 | Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. | 24 |
| 24554715 | 2014 | Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. | 24 |
| 22262837 | 2012 | Solution structure analysis of cytoplasmic domain of podocyte protein Neph1 using small/wide angle x-ray scattering (SWAXS). | 7 |
Citation
Dessen P
KIRREL1 (kirre like nephrin family adhesion molecule 1)
Atlas Genet Cytogenet Oncol Haematol. 2017-09-01
Online version: http://atlasgeneticsoncology.org/gene/79331/kirrel1-(kirre-like-nephrin-family-adhesion-molecule-1)
