The BIN1 gene encodes a set of BAR adapter proteins generated by alternate RNA splicing which function in membrane and actin dynamics, cell polarity and stress signaling. In cancer cells, BIN1 functions as a tumor suppressor gene and it is commonly silenced or misspliced during malignant progression. Genetic investigations in fission yeast, flies, mice and human cells suggest that BIN1 adapter proteins exert a moonlighting function in the nucleus, integrating cell polarity signals generated by actin and vesicle dynamics with central regulators of cell cycle control, apoptosis, and immune surveillance (adapted from Prendergast et al., 2009).
NCBI: 274 MIM: 601248 HGNC: 1052 Ensembl: ENSG00000136717
dbSNP: 274 ClinVar: 274 TCGA: ENSG00000136717 COSMIC: BIN1
Sunil Thomas ; Mee Young Chang ; George C Prendergast
BIN1 (Bridging Integrator 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-05-01
Online version: http://atlasgeneticsoncology.org/gene/794/meetings/js/lib/js/lib/jquery-3.5.1.min.js
2008-09-01 BIN1 (Bridging Integrator 1) by Mee Young Chang,George C Prendergast  Affiliation