BLK (BLK proto-oncogene, Src family tyrosine kinase)

2003-08-01  

Identity

HGNC
LOCATION
8p23.1
LOCUSID
ALIAS
MODY11
FUSION GENES

Other Information

Locus ID:

NCBI: 640
MIM: 191305
HGNC: 1057
Ensembl: ENSG00000136573

Variants:

dbSNP: 640
ClinVar: 640
TCGA: ENSG00000136573
COSMIC: BLK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136573ENST00000259089P51451
ENSG00000136573ENST00000529894E9PJX5
ENSG00000136573ENST00000645242E9PJX5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersREACTOMER-HSA-983695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367972562023B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin.11
367972562023B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin.11
351083812022Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY.13
351083812022Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY.13
337561602021BLK and BANK1 variants and interactions are associated with susceptibility for primary Sjögren's syndrome and with some clinical features.2
346375832021BLK polymorphisms and expression level in neuromyelitis optica spectrum disorder.5
337561602021BLK and BANK1 variants and interactions are associated with susceptibility for primary Sjögren's syndrome and with some clinical features.2
346375832021BLK polymorphisms and expression level in neuromyelitis optica spectrum disorder.5
323131952020Polymorphisms of BLK are associated with renal disorder in patients with systemic lupus erythematosus.1
323131952020Polymorphisms of BLK are associated with renal disorder in patients with systemic lupus erythematosus.1
305899372019Associations of secreted phosphoprotein 1 and B lymphocyte kinase gene polymorphisms with autoimmune thyroid disease.3
311018142019Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus.40
311343042019BLK and BANK1 polymorphisms and interactions are associated in Mexican patients with systemic lupus erythematosus.5
305899372019Associations of secreted phosphoprotein 1 and B lymphocyte kinase gene polymorphisms with autoimmune thyroid disease.3
311018142019Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus.40

Citation

Dessen P

BLK (BLK proto-oncogene, Src family tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/802/blk-(blk-proto-oncogene-src-family-tyrosine-kinase)