RXYLT1 (ribitol xylosyltransferase 1)

2018-11-01  

Identity

HGNC
LOCATION
12q14.2
LOCUSID
ALIAS
HP10481,MDDGA10,TMEM5

Other Information

Locus ID:

NCBI: 10329
MIM: 605862
HGNC: 13530
Ensembl: ENSG00000118600

Variants:

dbSNP: 10329
ClinVar: 10329
TCGA: ENSG00000118600
COSMIC: RXYLT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118600ENST00000261234Q9Y2B1
ENSG00000118600ENST00000537373G3V1K2
ENSG00000118600ENST00000543342F5GXF8

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
Mannose type O-glycan biosynthesisKEGGko00515
Mannose type O-glycan biosynthesisKEGGhsa00515

References

Pubmed IDYearTitleCitations
360071942024RETINAL MANIFESTATIONS OF WALKER-WARBURG SYNDROME IN TWO SIBLINGS WITH RXYLT1 MUTATIONS.0
360071942024RETINAL MANIFESTATIONS OF WALKER-WARBURG SYNDROME IN TWO SIBLINGS WITH RXYLT1 MUTATIONS.0
294778422018Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5.5
294778422018Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5.5
271307322016The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition.66
277336792016The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol β1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan.34
271307322016The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition.66
277336792016The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol β1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan.34
232173292012Identification of mutations in TMEM5 and ISPD as a cause of severe cobblestone lissencephaly.65
232173292012Identification of mutations in TMEM5 and ISPD as a cause of severe cobblestone lissencephaly.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

RXYLT1 (ribitol xylosyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/80361/rxylt1-(ribitol-xylosyltransferase-1)