CXCR5 (C-X-C motif chemokine receptor 5)

2003-02-01  

Identity

HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
BLR1,CD185,MDR15
FUSION GENES

Other Information

Locus ID:

NCBI: 643
MIM: 601613
HGNC: 1060
Ensembl: ENSG00000160683

Variants:

dbSNP: 643
ClinVar: 643
TCGA: ENSG00000160683
COSMIC: CXCR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160683ENST00000292174P32302
ENSG00000160683ENST00000292174A0N0R2

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217854302011Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions.384
240353652013Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses.306
241388842013Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.203
214714432011CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses.136
120700012002Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.85
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
176526192007Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia.57
192289232009Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting.55
267526442016CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5.50
170157142006CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production.46

Citation

Dessen P

CXCR5 (C-X-C motif chemokine receptor 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/805/cxcr5-(c-x-c-motif-chemokine-receptor-5)