INAVA (innate immunity activator)

2018-11-01  

Identity

HGNC
INAVA
LOCATION
1q32.1
LOCUSID
55765
ALIAS
C1orf106

Other Information

Locus ID:

NCBI: 55765
MIM: 618051
HGNC: 25599
Ensembl: ENSG00000163362

Variants:

dbSNP: 55765
ClinVar: 55765
TCGA: ENSG00000163362
COSMIC: INAVA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163362ENST00000367342Q3KP66
ENSG00000163362ENST00000413687Q3KP66
ENSG00000163362ENST00000451872C9JAT8
ENSG00000163362ENST00000532631E9PK29

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
342514162021Small-molecule modulators of INAVA cytosolic condensate and cell-cell junction assemblies.3
342514162021Small-molecule modulators of INAVA cytosolic condensate and cell-cell junction assemblies.3
294202622018C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.59
303554482018INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.12
310226982018Inflammatory Bowel Disease Susceptibility Gene C1ORF106 Regulates Intestinal Epithelial Permeability.5
294202622018C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.59
303554482018INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.12
310226982018Inflammatory Bowel Disease Susceptibility Gene C1ORF106 Regulates Intestinal Epithelial Permeability.5
284369392017An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.14
284369392017An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.14
279806952016Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis.17
279806952016Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis.17

Citation

Dessen P

INAVA (innate immunity activator)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/80641/inava-(innate-immunity-activator)