ATF1 (activating transcription factor 1)
1999-11-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
12q13.12
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
EWS-ATF1,FUS/ATF-1,TREB36
FUSION GENES
DNA/RNA
Transcription
816 bp mRNA
Proteins
Description
271 amino acids; possess a basic motif and a leucine-zipper; dimerisation with other ATF family members (e.g. ATF-1 homodimers and ATF-1/CREB heterodimers)
Localisation
nuclear
Function
DNA binding protein, binds the consensus sequence: 5GTGACGT(A/C)(A/G)-3; cAMP-inducible transcription factor (cAMP-responsive enhancer-binding protein (CRE), like CREB
Homology
members of the CREB protein family
Implicated in
Entity name
malignant melanoma of soft parts
Disease
very rare neuroectodermal tumour
Prognosis
very poor
Cytogenetics
characterised by the translocation t(12;22)(q13;q12)
Hybrid gene
5 EWSR1- 3 ATF1
Fusion protein
the chimaeric protein is composed of the N-terminal domain of EWS linked to the bZIP domain of ATF-1
Oncogenesis
binds to ATF sites present in cAMP-responsive promoters via the ATF1 bZIP domain and activates transcription constitutively, dependent on the activation domain (EAD) present in EWSR1
Breakpoints
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9398163 | 1997 | ATF1 and CREB trans-activate a cell cycle regulated histone H4 gene at a distal nuclear matrix associated promoter element. | Guo B et al |
| 9569031 | 1998 | The EWS/ATF1 fusion protein contains a dispersed activation domain that functions directly. | Pan S et al |
| 1655749 | 1991 | The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. | Rehfuss RP et al |
| 2196176 | 1990 | Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. | Yoshimura T et al |
| 8401579 | 1993 | EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. | Zucman J et al |
Other Information
Locus ID:
NCBI: 466
MIM: 123803
HGNC: 783
Ensembl: ENSG00000123268
Variants:
dbSNP: 466
ClinVar: 466
TCGA: ENSG00000123268
COSMIC: ATF1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38531792 | 2024 | Upregulated ATF1 Promotes Lipopolysaccharide Induced Inflammatory Response and Inhibits Osteogenic Differentiation of Human Periodontal Ligament Cells by Regulating NF-κB Pathway. | 1 |
| 38531792 | 2024 | Upregulated ATF1 Promotes Lipopolysaccharide Induced Inflammatory Response and Inhibits Osteogenic Differentiation of Human Periodontal Ligament Cells by Regulating NF-κB Pathway. | 1 |
| 37158648 | 2023 | ATF1 promotes the malignancy of lung adenocarcinoma cells by transcriptionally regulating ZNF143 expression. | 0 |
| 37158648 | 2023 | ATF1 promotes the malignancy of lung adenocarcinoma cells by transcriptionally regulating ZNF143 expression. | 0 |
| 32644859 | 2022 | Circ_0000745 Promotes the Progression of Cervical Cancer by Regulating miR-409-3p/ATF1 Axis. | 6 |
| 35397606 | 2022 | Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer. | 2 |
| 36041632 | 2022 | Protein arginine methyltransferase 5 is essential for oncogene product EWSR1-ATF1-mediated gene transcription in clear cell sarcoma. | 3 |
| 36154610 | 2022 | ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction. | 1 |
| 32644859 | 2022 | Circ_0000745 Promotes the Progression of Cervical Cancer by Regulating miR-409-3p/ATF1 Axis. | 6 |
| 35397606 | 2022 | Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer. | 2 |
| 36041632 | 2022 | Protein arginine methyltransferase 5 is essential for oncogene product EWSR1-ATF1-mediated gene transcription in clear cell sarcoma. | 3 |
| 36154610 | 2022 | ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction. | 1 |
| 33369218 | 2021 | Functional characterization of ATF1, GREM2 AND WNT10B variants associated with tooth agenesis. | 3 |
| 33827033 | 2021 | Integrative sequencing discovers an ATF1-motif enriched molecular signature that differentiates hyalinizing clear cell carcinoma from mucoepidemoid carcinoma. | 4 |
| 34121509 | 2021 | Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients. | 5 |
Citation
Jean-Loup Huret
ATF1 (activating transcription factor 1)
Atlas Genet Cytogenet Oncol Haematol. 1999-11-01
Online version: http://atlasgeneticsoncology.org/gene/81/atf1
