BMP6 (bone morphogenetic protein 6)

2003-11-01  

Identity

HGNC
BMP6
LOCATION
6p24.3
LOCUSID
654
ALIAS
VGR,VGR1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 654
MIM: 112266
HGNC: 1073
Ensembl: ENSG00000153162

Variants:

dbSNP: 654
ClinVar: 654
TCGA: ENSG00000153162
COSMIC: BMP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153162ENST00000283147P22004

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
BMP signalingKEGGhsa_M00679
BMP signalingKEGGM00679

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379305172024Bone morphogenetic protein 6 induces downregulation of pentraxin 3 expression in human granulosa lutein cells in women with polycystic ovary syndrome.0
383233522024BMP6 and VDR gene polymorphisms are associated with osteonecrosis in a sickle cell anaemia cohort.0
379305172024Bone morphogenetic protein 6 induces downregulation of pentraxin 3 expression in human granulosa lutein cells in women with polycystic ovary syndrome.0
383233522024BMP6 and VDR gene polymorphisms are associated with osteonecrosis in a sickle cell anaemia cohort.0
377956362023BMP6 participates in the pathogenesis of adolescent idiopathic scoliosis by regulating osteopenia.0
377956362023BMP6 participates in the pathogenesis of adolescent idiopathic scoliosis by regulating osteopenia.0
350331262022Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.1
356949252022Blood BMP6 Associated with Cognitive Performance and Alzheimer's Disease Diagnosis: A Longitudinal Study of Elders.2
361533212022RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.3
350331262022Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.1
356949252022Blood BMP6 Associated with Cognitive Performance and Alzheimer's Disease Diagnosis: A Longitudinal Study of Elders.2
361533212022RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.3
314952452021Bone morphogenetic protein 6 expression in cumulus cells is negatively associated with oocyte maturation.2
325245772021BMP-6 and SMAD4 gene expression is altered in cumulus cells from women with endometriosis-associated infertility.12
332327992021BMP6 binding to heparin and heparan sulfate is mediated by N-terminal and C-terminal clustered basic residues.3

Citation

Dessen P

BMP6 (bone morphogenetic protein 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/813/bmp6-(bone-morphogenetic-protein-6)