BMPR2 (bone morphogenetic protein receptor type 2)

2003-11-01  

Identity

HGNC
LOCATION
2q33.1
LOCUSID
ALIAS
BMPR-II,BMPR3,BMR2,BRK-3,POVD1,PPH1,T-ALK
FUSION GENES

Other Information

Locus ID:

NCBI: 659
MIM: 600799
HGNC: 1078
Ensembl: ENSG00000204217

Variants:

dbSNP: 659
ClinVar: 659
TCGA: ENSG00000204217
COSMIC: BMPR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204217ENST00000374574Q13873
ENSG00000204217ENST00000374580Q13873
ENSG00000204217ENST00000638587A0A1W2PPB5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
TGF-beta signaling pathwayKEGGko04350
Axon guidanceKEGGko04360
Cytokine-cytokine receptor interactionKEGGhsa04060
TGF-beta signaling pathwayKEGGhsa04350
Axon guidanceKEGGhsa04360
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
BMP signalingKEGGhsa_M00679
BMP signalingKEGGM00679
Signal TransductionREACTOMER-HSA-162582
Signaling by BMPREACTOMER-HSA-201451
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193900562009Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway.156
117146952002The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.141
260760382015Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.118
164293952006Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension.117
243556372013Genetics and genomics of pulmonary arterial hypertension.90
150312602004Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
196287802009Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertension.83
218219172011Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival.83
193571542009Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females.80

Citation

Dessen P

BMPR2 (bone morphogenetic protein receptor type 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/818/bmpr2-(bone-morphogenetic-protein-receptor-type-2)